Polygenic Risk Scores (PRS)

Helper

We have calculated lists of SNPs for each trait using OpenGWAS summary statistics and LD patterns from European and African individuals. SNP lists are derived using clumping-and-thresholding (PLINK2) followed by conditional analysis (COJO). The package used to derive these SNPs is GWASum, available at https://github.com/holstegelab/GWASum. With these lists of SNPs, you can then use jordan or polygenenius to calculate PRS in your own data.

Note that SNP lists are not manually curated. Ancestry-specific lists are shown where African data are selected and available.

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