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Polygenic Risk Scores (PRS)

Search traits of interest, get SNPs, make PRS. Easy.

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Type to search and select one trait.

Helper

We have calculated lists of SNPs for each trait using publicly available GWAS summary statistics and publicly available LD patterns from TopMed. You may want to further filter the SNPs based on the p-value threshold or other criteria before using them in your analyses. You can then use jordan or polygenenius to calculate PRS in your own data.

Note that SNP lists are not manually curated, largely based on individuals of European ancestry, and may result in a larger number of SNPs.

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PRS with Jordan

jordan --genotype {your genotype data} --snplist {individual SNP list as downloaded above} --outname {output folder} [options: --dosages --keepDos --maf 0.01]

For more info, visit Jordan at GitHub.

PRS with Polygenius

For more info visit Polygenius at the Holstegelab page.